Article
Prediction of bone density from vitamin D receptor alleles.
Nature - 20 Jan 1994
Morrison N A, Qi J C, Tokita A, Kelly P J, Crofts L, Nguyen T V, Sambrook P N, Eisman J A
Abstract excerpt
Bone density achieved in early adulthood is the major determinant of risk of osteoporotic fracture. Up to 60% of women suffer osteoporotic fractures as a result of low bone density, which is under strong genetic control acting through effects on bone turnover. Here we show that common allelic variants in the gene encoding the vitamin D receptor can be used to predict differences in bone density, accounting for up...
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