Genetic influences on bone density: physiological correlates of vitamin D receptor gene alleles in premenopausal women.

doi:10.1210/jcem.80.9.7673427

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Article

Genetic influences on bone density: physiological correlates of vitamin D receptor gene alleles in premenopausal women.

The Journal of clinical endocrinology and metabolism - 1 Sept 1995

Howard G, Nguyen T, Morrison N, Watanabe T, Sambrook P, Eisman J, Kelly P J

Abstract excerpt

Common vitamin D receptor (VDR) gene alleles have recently been shown to contribute to the genetic variability in bone mass and bone turnover, however, the physiological mechanisms involved are unknown. To examine this, the response to 7 days of 2 micrograms oral 1,25-dihydroxyvitamin D[1,25-(OH)2D] (calcitriol) stimulation was assessed in 21 premenopausal women, homozygous for one or other of the common VDR...

Topics

Adult
Alleles
Bone Density
Bone and Bones
Calcitriol
Calcium
Collagen
Collagen Type I
Female
Genes
Homeostasis
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Osteocalcin

Peptides

Phosphates

Premenopause

Receptors, Calcitriol

Source

Open in PubMed

Identifiers

PMID: 7673427
DOI: 10.1210/jcem.80.9.7673427

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7673427-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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