Article
Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats.
Brain research. Molecular brain research - 1 Jun 1992
Lachman H M, Papolos D F, Weiner E D, Ramazankhana R, Hartnick C, Edwards E, Henn F A
Abstract excerpt
The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is invo...
Topics
- Amino Acid Isomerases
- Animals
- Association Learning
- Carrier Proteins
- Cerebral Cortex
- Disease Susceptibility
- Enkephalins
- Escape Reaction
- Gene Expression
- Genetic Predisposition to Disease
- Helplessness, Learned