Article
Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats.
Brain research. Molecular brain research - 1 Jun 1992
Lachman H M, Papolos D F, Weiner E D, Ramazankhana R, Hartnick C, Edwards E, Henn F A
Abstract excerpt
The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned...
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