Article
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations.
Nature - 16 Jul 1992
Morgan B A, Izpisúa-Belmonte J C, Duboule D, Tabin C J
Abstract excerpt
In the limb bud the 5' members of the Hox-4 gene cluster are expressed in a nested set of overlapping domains which are progressively restricted in the posterior and distal directions. These domains arise early in limb bud development and come to approximate the primordia of the major structural elements of the limb along the anterior/posterior axis (Fig. 1). This pattern, and the fact that surgical manipulations...
Topics
- Animals
- Animals, Genetically Modified
- Bone and Bones
- Chick Embryo
- Extremities
- Gene Expression
- Genes, Homeobox
- Multigene Family
- Phenotype
- RNA, Messenger
- Transformation, Genetic