Article
No independent association between HSP70 gene polymorphism and IDDM.
Diabetes - 1 Jul 1992
Pugliese A, Awdeh Z L, Galluzzo A, Yunis E J, Alper C A, Eisenbarth G S
Abstract excerpt
A role for heat shock proteins (HSPs) in autoimmunity has recently been suggested by several authors. Autoantibodies against HSPs have been associated with such autoimmune diseases as systemic lupus erythematosus, polymyositis, and the NOD mouse model of diabetes. Moreover, genes for the major 70...
Topics
- Alleles
- Autoantibodies
- Blotting, Southern
- Chromosomes, Human, Pair 6
- DNA
- Follow-Up Studies
- Genes, MHC Class I
- Genes, MHC Class II
- HLA-DR Antigens
- Haplotypes
- Heat-Shock Proteins
- Humans
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length