Article
Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes.
Clinical science (London, England : 1979) - 1 Jan 2009
Buraczynska Monika, Swatowski Andrzej, Buraczynska Kinga, Dragan Michal, Ksiazek Andrzej
Abstract excerpt
HSPs (heat-shock proteins) are molecular chaperones synthesized under stress conditions, and are involved in renal cell survival and matrix remodelling in acute and chronic renal diseases. In the present study, we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with...
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