Article
Strong association of insulin autoimmune syndrome with HLA-DR4.
Lancet (London, England) - 15 Feb 1992
Uchigata Y, Kuwata S, Tokunaga K, Eguchi Y, Takayama-Hasumi S, Miyamoto M, Omori Y, Juji T, Hirata Y
Abstract excerpt
Insulin autoimmune syndrome is characterised by spontaneous hypoglycaemia without evidence of exogenous insulin administration, a high serum concentration of total immunoreactive insulin, and the presence of insulin autoantibodies in high titre. HLA typing of 27 patients with insulin autoimmune syndrome showed that all had DR4, which was present in only 43% of 51 healthy controls (odds ratio 72.1, p less than 2 x...
Topics
- Adult
- Aged
- Alleles
- Autoantibodies
- Autoimmune Diseases
- Female
- Genes, MHC Class II
- HLA Antigens
- HLA-DR4 Antigen
- Humans
- Hypoglycemia
- Insulin