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Article

Human immunodeficiency virus (HIV) type 1 can superinfect HIV-2-infected cells: pseudotype virions produced with expanded cellular host range.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1992

Le Guern M, Levy J A

Abstract excerpt

In studies on viral interference, cloned T-cell lines chronically infected with human immunodeficiency virus (HIV) type 1 or HIV-2 were inoculated with several strains of these two AIDS retrovirus subtypes. HIV-2UC1-infected cells, which still express the CD4 receptor, could be superinfected with a variety of HIV-1 and HIV-2 strains. This event was accompanied by cytopathic effects in the cells and production of...

Topics

B-Lymphocytes
CD4-Positive T-Lymphocytes
Cytopathogenic Effect, Viral
HIV Antigens
HIV Infections
HIV-1
HIV-2
Humans
In Vitro Techniques
Neutralization Tests
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1346069
DOI: 10.1073/pnas.89.1.363
PMCID: PMC48237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1346069-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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