Article
Molecular and biological interactions between two HIV-1 strains from a coinfected patient reveal the first evidence in favor of viral synergism.
Virology - 15 Aug 2000
Wang B, Lal R B, Dwyer D E, Miranda-Saksena M, Boadle R, Cunningham A L, Saksena N K
Abstract excerpt
An intravenous drug user was found to be dually infected with two genetically and phylogenetically distinct human immunodeficiency virus type 1 (HIV-1) subtype B strains (designated groups I and II). Viral isolation revealed a simultaneous copassaging of two strains in PBMC. The culture of viral strains on monocytes and monocyte-derived macrophages preferentially segregated the two viral strains. The group I...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- Female
- Gene Products, vpr
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Microscopy, Electron
- Molecular Sequence Data
- Peptide Fragments
- Phenotype
- Phylogeny