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The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS Cells

30 Dec 2014

Abstract excerpt

The human osteosarcoma cell line U2OS is useful for studying genome replication of human papillomavirus (HPVs) subtypes that belong to different phylogenetic genera. In this study, we defined the HPV18 transcription map in U2OS cells during transient replication, stable maintenance and vegetative amplification by identifying viral promoter regions, transcription polyadenylation and splicing sites during HPV18...

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PMID: 25548925
DOI: 10.1371/journal.pone.0116151

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