Article
A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter
1 Jan 1995
Abstract excerpt
YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) in HeLa cells, which are known for high-level expression of the HPV-18 early genes. The activating activity of YY1 is dependent on the presence of a newly identified switch...