Article
T-cell receptor beta chain gene rearrangement in acute myeloid leukemia always occurs at the allele that contains the undermethylated J beta 1 region.
Cancer research - 1 Dec 1992
Ohyashiki J H, Ohyashiki K, Kawakubo K, Tauchi T, Nakazawa S, Kimura N, Toyama K
Abstract excerpt
The epigenetic phenomenon could play a role in the interaction between chromatin and DNA-binding enzymes, allowing us to consider an association between the phenomenon and gene rearrangement. The correlation between methylation status and rearrangement of the T-cell receptor (TCR) beta chain gene in leukemia cells obtained from patients with acute myeloid leukemia (AML) was examined. All of the AML patients with...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- DNA, Neoplasm
- Female
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Granulocytes
- Humans
- Karyotyping
- Leukemia, Myeloid, Acute