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Article

Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation

4 Jan 2023

Abstract excerpt

Introduction: Upon BMP-2 stimulation, the osteoblastic lineage commitment in C2C12 myoblasts is associated with a microenvironmental change that occurs over several days. How does BMP-2 operate a switch in adhesive machinery to adapt to the new microenvironment and to drive bone cell fate is not well understood. Here, we addressed this question for BMP-2 delivered either in solution or physically bound of a...

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Identifiers

PMID: 36684447
DOI: 10.3389/fcell.2022.1027334

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