Article
Human placental cells transformed with temperature-sensitive simian virus 40 are immortalized and mimic the phenotype of invasive cytotrophoblasts at both permissive and nonpermissive temperatures.
Cancer research - 1 Nov 1992
Logan S K, Fisher S J, Damsky C H
Abstract excerpt
Establishment of the human placenta is essential for subsequent development of the embryo. Previous studies from our laboratories have demonstrated that chorionic villus cytotrophoblast stem cells undergo a stepwise differentiation process in vivo that results in their ability to invade the uterine wall. This process can be mimicked by isolated primary first-trimester cytotrophoblasts in vitro. Efforts to study...
Topics
- Cell Adhesion Molecules
- Cell Transformation, Viral
- Cells, Cultured
- Chorionic Gonadotropin
- Collagen
- Drug Combinations
- Female
- Humans
- Laminin
- Metalloendopeptidases
- Molecular Weight