Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies.

Experimental cell research - 15 Jul 2004

Korff Thomas, Krauss Thomas, Augustin Hellmut G

Abstract excerpt

Normal placental development is dependent on the orchestrated differentiation of cytotrophoblast (CTB) cells. This study was aimed at studying cytotrophoblast cells from normal and preeclamptic pregnancies in a three-dimensional spheroid-based cell culture model. First trimester cytotrophoblast cells cultured as spheroids maintain their high proliferative and invasive phenotype and respond to different cytokines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiopoietin-2
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Pre-Eclampsia

Share to Pregnancy Proteins

Share to Pregnancy Trimester, First

Share to Pregnancy Trimester, Third

Share to Spheroids, Cellular

Share to Trophoblasts

Source

Identifiers

PMID: 15212944
DOI: 10.1016/j.yexcr.2004.03.043

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies.PMID 15212944Read ↗

Characterization of Three-Dimensional Trophoblast Spheroids: An Alternative Model to Study the Physiological Properties of the Placental UnitSemantic proximity Read ↗

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?Semantic proximity Read ↗

Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsiaSemantic proximity Read ↗

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human PlacentaSemantic proximity Read ↗

The Human Placenta Remodels the Uterus by Using a Combination of Molecules That Govern Vasculogenesis or Leukocyte ExtravasationSemantic proximity Read ↗

Cytotrophoblast stem cell lines derived from human embryonic stem cells and their capacity to mimic invasive implantation eventsSemantic proximity Read ↗

In Vitro Model of Human Trophoblast in Early PlacentationSemantic proximity Read ↗

The first trimester human trophoblast cell line ACH-3P: A novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations – TNF-α stimulates MMP15 expressionSemantic proximity Read ↗

Validation of the Sw71‐spheroid model with primary trophoblast cellsSemantic proximity Read ↗

Investigation of human trophoblast invasion in vitroSemantic proximity Read ↗

Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interfaceSemantic proximity Read ↗

Functional HLA-C expressing trophoblast spheroids as a model to study placental–maternal immune interactions during human implantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.