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Article

Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-I.

International journal of antimicrobial agents - 1 May 2014

Huang Yanqin, Xu Yunhua, Liu Shicong, Wang Hailin, Xu Xiaogang, Guo Qinglan, Wu Baixue, Gordeev Mikhail F, Wang Wen, Yuan Zhengyu, Wang Minggui

Abstract excerpt

MRX-I is a new oxazolidinone antimicrobial under development. In this study, the potential for development of resistance to MRX-I in Staphylococcus aureus was investigated and key mutations were characterised. Determination of spontaneous resistance frequency and the mutant selection window (MSW) were performed with meticillin-susceptible S. aureus (MSSA) ATCC 29213, meticillin-resistant S. aureus (MRSA) ATCC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24721233
DOI: 10.1016/j.ijantimicag.2014.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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