Emergence of quinolone-imipenem cross-resistance in Pseudomonas aeruginosa after fluoroquinolone therapy.

doi:10.1093/jac/29.3.307

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Article

Emergence of quinolone-imipenem cross-resistance in Pseudomonas aeruginosa after fluoroquinolone therapy.

The Journal of antimicrobial chemotherapy - 1 Mar 1992

Aubert G, Pozzetto B, Dorche G

Abstract excerpt

Emergence of resistance to fluoroquinolones was observed in two clinical isolates of Pseudomonas aeruginosa after ciprofloxacin or norfloxacin monotherapy. In the first case, the resistant variants exhibited quinolone-imipenem cross-resistance (MIC of norfloxacin and ciprofloxacin: 16 mg/L; MIC o...

Topics

Anti-Infective Agents
Drug Resistance, Microbial
Drug Therapy, Combination
Fluoroquinolones
Humans
Imipenem
Microbial Sensitivity Tests
Mutation
Naphthyridines
Norfloxacin
Pseudomonas Infections
Pseudomonas aeruginosa
Quinolones

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