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Development of quinolone-imipenem cross resistance in Pseudomonas aeruginosa during exposure to ciprofloxacin

1 Nov 1990

Abstract excerpt

Selection and regrowth of ciprofloxacin-resistant variants, which were present in low frequencies in the initial inoculum, were seen when large inocula of Pseudomonas aeruginosa were incubated with ciprofloxacin. These variants showed cross resistance to other quinolones. In 8 of 13 strains tested, ciprofloxacin selected imipenem-resistant variants in a similar way to imipenem. The opposite phenomenon of...

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PMID: 2127345
DOI: 10.1128/aac.34.11.2142

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