Article
Effect of beta-lactam antibiotics on the in vitro development of resistance in Pseudomonas aeruginosa.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Mar 2001
Carsenti-Etesse H, Cavallo J D, Roger P M, Ziha-Zarifi I, Plesiat P, Garrabé E, Dellamonica P
Abstract excerpt
OBJECTIVE: To investigate whether stepwise selection of resistance mutations may mirror the continued bacterial exposure to antibiotics that occurs in the clinical setting. METHODS: We examined the in vitro development of resistance to a number of commonly used antibiotics (cefepime, cefpirome, ceftazidime, cefotaxime, piperacillin and imipenem) in Pseudomonas aeruginosa, a significant nosocomial pathogen....
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