Article
Intragenic suppressors reveal long distance interactions between inactivating and reactivating amino acid replacements generating three-dimensional constraints in the structure of mitochondrial cytochrome b.
The Journal of biological chemistry - 15 Sept 1990
di Rago J P, Netter P, Slonimski P P
Abstract excerpt
Revertants of nonfunctional cytochrome b mutants were isolated and characterized to determine how specific deleterious mutations in cytochrome b can be suppressed by secondary mutations not restoring a wild type protein. It was recently shown that the cytochrome b function can be recovered follow...
Topics
- Amino Acid Sequence
- Base Sequence
- Codon
- Cytochrome b Group
- Exons
- Intracellular Membranes
- Introns
- Macromolecular Substances
- Mitochondria
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Saccharomyces cerevisiae
- Suppression, Genetic