Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

doi:10.1002/j.1460-2075.1992.tb05209.x

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Article

Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

The EMBO journal - 1 Apr 1992

Jia Z P, McCullough N, Martel R, Hemmingsen S, Young P G

Abstract excerpt

We have identified a new locus, sodium 2 (sod2) based on selection for increased LiCl tolerance in fission yeast, Schizosaccharomyces pombe. Tolerant strains have enhanced pH-dependent Na+ export capacity and sodium transport experiments suggest that the gene encodes an Na+/H+ antiport. The predicted sod2 gene product can be placed in the broad class of transporters which possess 12 hydrophobic transmembrane...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Blotting, Southern
Carrier Proteins
Chlorides
Cloning, Molecular
DNA, Fungal
Drug Resistance, Microbial
Escherichia coli
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Fungal

Humans

Hydrogen-Ion Concentration

Kinetics

Lithium

Lithium Chloride

Models, Structural

Source

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Identifiers

PMID: 1314171
DOI: 10.1002/j.1460-2075.1992.tb05209.x
PMCID: PMC556613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1314171-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.PMID 1314171Read ↗

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