Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.

doi:10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820690929>3.0.co;2-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.

Cancer - 1 May 1992

Brüstle O, Ohgaki H, Schmitt H P, Walter G F, Ostertag H, Kleihues P

Abstract excerpt

Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intrathecal methotrexate. The brain tumors had histologic and immunohistochemical features of primitive...

Topics

Aspartic Acid
Base Sequence
Brain Neoplasms
Child
Child, Preschool
Codon
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Glycine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Neoplasms, Germ Cell and Embryonal

Neoplasms, Radiation-Induced

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1314130
DOI: 10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820690929>3.0.co;2-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1314130-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.PMID 1314130Read ↗

Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study.Semantic proximity Read ↗

Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues.Semantic proximity Read ↗

Adult neuroectodermal tumors of posterior fossa (medulloblastoma) and of supratentorial sites (stPNET).Semantic proximity Read ↗

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors.Semantic proximity Read ↗

Molecular pathogenesis of adult brain tumors and the role of stem cells.Semantic proximity Read ↗

Neuro-oncogenesis. A review.Semantic proximity Read ↗

Molecular Basis of Pediatric Brain Tumors.Semantic proximity Read ↗

Radiation-Induced Gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.