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Article

Dominant rearrangements among human tumor-infiltrating lymphocytes. Analysis of T-cells derived from 32 patients with melanoma, lung, and renal cell carcinoma.

Cancer - 1 May 1992

Bennett W T, Pandolfi F, Grove B H, Hawes G E, Boyle L A, Kradin R L, Kurnick J T

Abstract excerpt

Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL). After interleukin-2 expansion of TIL from renal and lung carcinoma and melanoma biopsy tissues, rearrangements of TCR beta-chain genes were analyzed by Southern blotting. Nongermline restriction fragments, indicating dominant rearrangements, were detected among the TIL from all 6 patients...

Topics

Carcinoma, Bronchogenic
Carcinoma, Renal Cell
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, Dominant
Humans
Kidney Neoplasms
Lung Neoplasms
Lymphocytes, Tumor-Infiltrating
Melanoma
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

T-Lymphocytes

Source

Identifiers

PMID: 1314129
DOI: 10.1002/1097-0142(19920501)69:9<2379::aid-cncr2820690928>3.0.co;2-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1314129-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dominant rearrangements among human tumor-infiltrating lymphocytes. Analysis of T-cells derived from 32 patients with melanoma, lung, and renal cell carcinoma.PMID 1314129Read ↗

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