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Article

VPg gene amplification correlates with infective particle formation in foot-and-mouth disease virus.

Journal of virology - 1 Apr 1992

Falk M M, Sobrino F, Beck E

Abstract excerpt

In order to analyze the function of VPg amplification in aphthoviruses, we have undertaken the first mutational analysis of the repetitive VPg-coding region using an improved foot-and-mouth disease virus (FMDV) cDNA clone from which infective viral RNA was synthesized. A set of VPg mutants was constructed by site-directed mutagenesis which includes different VPg deletion mutations, a VPg insertion mutation, and...

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Identifiers

PMID: 1312630
DOI: 10.1128/JVI.66.4.2251-2260.1992
PMCID: PMC289018

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