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Article

Localization of the exonuclease and polymerase domains of Bacillus subtilis DNA polymerase III.

Gene - 1 Feb 1992

Barnes M H, Hammond R A, Kennedy C C, Mack S L, Brown N C

Abstract excerpt

Structural gene mutants were cloned and exploited to identify the major catalytic domains of Bacillus subtilis DNA polymerase III (BsPolIII), a 162.4-kDa [1437 amino acids (aa)] polymerase: 3'-5' exonuclease (Exo) required for replicative DNA synthesis. Analysis of the sequence, mutagenicity, and catalytic behavior of natural and site-directed point mutants of BsPolIII unequivocally located the domain involved in...

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Source

Identifiers

PMID: 1312503
DOI: 10.1016/0378-1119(92)90601-k

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