Article
The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system.
Virology - 1 Mar 1992
Fazakerley J K, Parker S E, Bloom F, Buchmeier M J
Abstract excerpt
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU. To determine the basis for this difference in neurovirulence we hav...
Topics
- Animals
- Brain
- Central Nervous System
- Coronaviridae Infections
- Encephalitis
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Murine hepatitis virus
- Mutation
- Nucleic Acid Hybridization
- Spike Glycoprotein, Coronavirus
- Spinal Cord
- Viral Envelope Proteins