The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.

doi:10.1128/JVI.66.1.469-479.1992

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Article

The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.

Journal of virology - 1 Jan 1992

Zhu L A, Weller S K

Abstract excerpt

The UL5 protein of herpes simplex virus type 1, one component of the viral helicase-primase complex, contains six sequence motifs found in all members of a superfamily of DNA and RNA helicases. Although this superfamily contains more than 20 members ranging from bacteria to mammalian cells and their viruses, the importance of these motifs has not been addressed experimentally for any one of them. In this study,...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
DNA Helicases
DNA Primase
DNA, Viral
Molecular Sequence Data
Multienzyme Complexes
Mutagenesis, Site-Directed
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Nucleotidyltransferases

Restriction Mapping

Sequence Alignment

Simplexvirus

Transfection

Vero Cells

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1309257
DOI: 10.1128/JVI.66.1.469-479.1992
PMCID: PMC238307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1309257-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.PMID 1309257Read ↗

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