Article
Expression of the PMP-22 gene in Trembler mutant mice: comparison with the other myelin protein genes.
Developmental neuroscience - 1 Jan 1992
Bascles L, Bonnet J, Garbay B
Abstract excerpt
The Trembler mouse suffers from a dominantly inherited autosomal mutation affecting the Schwann cell activities, which results in an abnormal myelination of the peripheral nervous system. Very recently, it has been shown that the mutation is in the PMP-22 gene. However, the level of expression of the mutated gene in trembler mice has not been studied. Therefore, we measured the steady-state levels of mRNA...
Topics
- Animals
- Base Sequence
- Gene Expression Regulation
- Genotype
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Myelin Proteins
- Polymerase Chain Reaction
- RNA, Messenger