Article
Hippocampal kindling increases the expression of glutamate receptor-A Flip and -B Flip mRNA in dentate granule cells.
Neuroscience letters - 14 Dec 1992
Kamphuis W, Monyer H, De Rijk T C, Lopes da Silva F H
Abstract excerpt
The level of the mRNAs encoding the AMPA-selective glutamate receptors-A and -B, alternatively splice variants, Flip and Flop, was studied by in situ hybridization in the brains of rats kindled by Schaffer collateral/commissural-fiber stimulation. In comparison to control animals, the expression level of the Flip variant of both GluR-A and GluR-B mRNAs was bilaterally enhanced in the dentate granule neurons of...
Topics
- Alternative Splicing
- Animals
- Electric Stimulation
- Evoked Potentials
- Genetic Variation
- Hippocampus
- Kindling, Neurologic
- Male
- Pyramidal Tracts
- RNA, Messenger
- Rats