Article
Phorbol ester-induced redistribution of the ASGP receptor is independent of receptor phosphorylation.
FEBS letters - 6 Jul 1992
Geffen I, Spiess M
Abstract excerpt
Like virtually all endocytic receptors, the human asialoglycoprotein (ASGP) receptor is phosphorylated by protein kinase C at serine residues within the cytoplasmic domains of its two subunits H1 and H2. Activation of protein kinase C by phorbol esters results in hyperphosphorylation and in a concomitant net redistribution of receptors to intracellular compartments (down-regulation) in HepG2 cells. To test...
Topics
- 3T3 Cells
- Animals
- Asialoglycoprotein Receptor
- Asialoglycoproteins
- Cell Line, Transformed
- Chlorocebus aethiops
- Down-Regulation
- Humans
- Mice
- Mutation
- Orosomucoid
- Phorbol 12,13-Dibutyrate