Membrane-bound versus secreted forms of human asialoglycoprotein receptor subunits. Role of a juxtamembrane pentapeptide.

doi:10.1074/jbc.271.24.14496

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Article

Membrane-bound versus secreted forms of human asialoglycoprotein receptor subunits. Role of a juxtamembrane pentapeptide.

The Journal of biological chemistry - 14 Jun 1996

Tolchinsky S, Yuk M H, Ayalon M, Lodish H F, Lederkremer G Z

Abstract excerpt

The H2a alternatively spliced variant of the human asialoglycoprotein receptor H2 subunit differs from the H2b variant by an extra pentapeptide, EGHRG, present in the ectodomain next to the membrane-span. This difference causes retention and degradation in the endoplasmic reticulum (ER) of H2a wh...

Topics

3T3 Cells
Alternative Splicing
Amino Acid Sequence
Animals
Antibodies
Asialoglycoprotein Receptor
Asialoglycoproteins
Biotin
Cell Membrane
Genetic Variation
Humans
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Macromolecular Substances

Mice

Molecular Sequence Data

Oligopeptides

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 8662943
DOI: 10.1074/jbc.271.24.14496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8662943-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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