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Article

Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification.

Developmental biology - 1 Jun 2005

Viviano Beth L, Silverstein Laura, Pflederer Camila, Paine-Saunders Stephenie, Mills Kathy, Saunders Scott

Abstract excerpt

Loss of function mutations in the gene encoding the heparan sulfate proteoglycan Glypican-3 (GPC3) causes an X-linked disorder in humans known as Simpson-Golabi-Behmel Syndrome (SGBS). This disorder includes both pre- and postnatal overgrowth, a predisposition to certain childhood cancers, and a...

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Source

Identifiers

PMID: 15936336
DOI: 10.1016/j.ydbio.2005.03.003

Genes

GPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15936336-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification.PMID 15936336Read ↗

Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.Semantic proximity Read ↗

Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition.Semantic proximity Read ↗

Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.Semantic proximity Read ↗

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.Semantic proximity Read ↗

Alterations in mandibular morphology associated with glypican 1 and glypican 3 gene mutations.Semantic proximity Read ↗

GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome.Semantic proximity Read ↗

Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in miceSemantic proximity Read ↗

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanismSemantic proximity Read ↗

Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.Semantic proximity Read ↗

A single heterozygous mutation in <i>COG4</i> disrupts zebrafish early development via Wnt signalingSemantic proximity Read ↗

Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.Semantic proximity Read ↗

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