Article
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.
The New England journal of medicine - 23 Apr 1992
Watkins H, Rosenzweig A, Hwang D S, Levi T, McKenna W, Seidman C E, Seidman J G
Abstract excerpt
BACKGROUND: Familial hypertrophic cardiomyopathy is characterized by a variable degree of myocardial hypertrophy and a wide range of symptoms. Different mutations in the beta cardiac myosin heavy-chain gene have been identified in three affected families. However, neither the proportion of cases attributable to myosin mutations nor the effects of different mutations on clinical outcome are known. METHODS: Using a...
Topics
- Amino Acid Sequence
- Cardiomyopathy, Hypertrophic
- Humans
- Mutation
- Myosins
- Prognosis