Article
A missense mutation in the beta myosin heavy chain gene is a predictor of premature sudden death in patients with hypertrophic cardiomyopathy.
The Journal of sports medicine and physical fitness - 1 Mar 1994
Marian A J, Kelly D, Mares A, Fitzgibbons J, Caira T, Qun-Tao, Hill R, Perryman M B, Roberts R
Abstract excerpt
BACKGROUND: Familial hypertrophic cardiomyopathy (FHCM) is an autosomal dominant disease with protean clinical manifestations, ranging from asymptomatic to that of severe heart failure or sudden death. There is no known parameter in individuals with hypertrophic cardiomyopathy (HCM) that predicts...
Topics
- Adult
- Base Sequence
- Cardiomyopathy, Hypertrophic
- DNA
- DNA Mutational Analysis
- Death, Sudden, Cardiac
- Female
- Genetic Testing
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Myosins
- Pedigree
- Phenotype