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Article

The role of tryptophan residues in an integral membrane protein: diacylglycerol kinase.

Biochemistry - 23 Sept 2003

Clark Elizabeth H, East J Malcolm, Lee Anthony G

Abstract excerpt

Tryptophan residues are thought to play special roles in integral membrane proteins, anchoring transmembrane alpha-helices into the lipid bilayer. We have studied the effect of mutating the five Trp residues in the diacylglycerol kinase (DGK) of Escherichia coli to Leu residues. The fluorescence emission maxima for DGK and a variety of Trp mutants in bilayers of dioleoylphosphatidylcholine [di(C18:1)PC] are all...

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Identifiers

PMID: 12974643
DOI: 10.1021/bi034607e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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