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Article

Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age

1 Nov 2003

Abstract excerpt

Autosomal recessive juvenile parkinsonism is a movement disorder associated with the degeneration of dopaminergic neurons in substantia nigra pars compacta. The loss of functional parkin caused by parkin gene mutations is the most common single cause of juvenile parkinsonism. Parkin has been shown to aid in protecting cells from endoplasmic reticulum and oxidative stressors presumably due to ubiquitin ligase...

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Identifiers

PMID: 12972409
DOI: 10.1074/jbc.m306889200

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Related research

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Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with AgePMID 12972409Read ↗

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