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Article

Lipoprotein (a) downregulates lysosomal acid lipase and induces interleukin-6 in human blood monocytes.

Biochimica et biophysica acta - 23 Sept 2003

Buechler Christa, Ullrich Heidrun, Aslanidis Charalampos, Bared Salim Maa, Lingenhel Arno, Ritter Mirko, Schmitz Gerd

Abstract excerpt

The association of elevated lipoprotein (a) (Lp(a)) with an increased risk for coronary events is clearly established. This increased risk may in part be due to the activation of monocytes as major cells involved in atherogenesis. High concentrations of plasma Lp(a) were shown to influence the gene expression of human blood monocytes and in the present study we demonstrate a reduced abundance of the lysosomal...

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Identifiers

PMID: 12972290
DOI: 10.1016/s0167-4889(03)00083-1

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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