Article
Apolipoprotein(a) induces monocyte chemotactic activity in human vascular endothelial cells.
Circulation - 21 Oct 1997
Poon M, Zhang X, Dunsky K G, Taubman M B, Harpel P C
Abstract excerpt
BACKGROUND: Elevated levels of lipoprotein(a) [Lp(a)] are associated with premature atherosclerosis; however, the mechanisms are not known. Recruitment of monocytes to the blood vessel wall is an early event in atherogenesis. METHODS AND RESULTS: This study has found that unoxidized Lp(a) induced human umbilical vein endothelial cells (HUVECs) to secrete monocyte chemotactic activity (MCA), whereas LDL under the...
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