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Article

Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response.

The Journal of biological chemistry - 2 Sept 2011

Frisdal Eric, Lesnik Philippe, Olivier Maryline, Robillard Paul, Chapman M John, Huby Thierry, Guerin Maryse, Le Goff Wilfried

Abstract excerpt

Cholesterol-laden monocyte-derived macrophages are phagocytic cells characteristic of early and advanced atherosclerotic lesions. Interleukin-6 (IL-6) is a macrophage secretory product that is abundantly expressed in atherosclerotic plaques but whose precise role in atherogenesis is unclear. The...

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Identifiers

PMID: 21757719
DOI: 10.1074/jbc.M111.264325
PMCID: PMC3162452

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21757719-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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