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Article

Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response.

The Journal of biological chemistry - 2 Sept 2011

Frisdal Eric, Lesnik Philippe, Olivier Maryline, Robillard Paul, Chapman M John, Huby Thierry, Guerin Maryse, Le Goff Wilfried

Abstract excerpt

Cholesterol-laden monocyte-derived macrophages are phagocytic cells characteristic of early and advanced atherosclerotic lesions. Interleukin-6 (IL-6) is a macrophage secretory product that is abundantly expressed in atherosclerotic plaques but whose precise role in atherogenesis is unclear. The capacity of macrophages to clear apoptotic cells, through the efferocytosis mechanism, as well as to reduce cellular...

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PMID: 21757719
DOI: 10.1074/jbc.M111.264325
PMCID: PMC3162452

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ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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