Article
Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup.
Leukemia - 1 Sept 2003
Gutierrez M I, Siraj A K, Bhargava M, Ozbek U, Banavali S, Chaudhary M A, El Solh H, Bhatia K
Abstract excerpt
Multiple genes have been shown to be independently hypermethylated in lymphoid malignancies. We report here on the extent of concurrent methylation of E-cadherin, Dap-kinase, O(6)MGMT, p73, p16, p15 and p14 in 129 pediatric ALL cases. While most of these genes demonstrated methylation in a proportion of cases, O(6)MGMT, p16 and p14 were infrequently methylated (11, 7 and 3%, respectively). Methylation of at least...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.