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Article

CpG island methylator phenotype classification improves risk assessment in pediatric T-cell acute lymphoblastic leukemia

22 Jan 2025

Abstract excerpt

ABSTRACT: Current intensive treatment of pediatric T-cell acute lymphoblastic leukemia (T-ALL) has substantial side effects, highlighting a need for novel biomarkers to improve risk stratification. Canonical biomarkers, such as genetics and immunophenotype, are largely not used in pediatric T-ALL stratification. This study aimed to validate the prognostic relevance of DNA methylation CpG island methylator...

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PMID: 39841000
DOI: 10.1182/blood.2024026027

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