Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.

The Journal of clinical endocrinology and metabolism - 1 Sept 2003

Collins Michael T, Sarlis Nicholas J, Merino Maria J, Monroe Jason, Crawford Susan E, Krakoff Jonathan A, Guthrie Lori C, Bonat Sandra, Robey Pamela G, Shenker Andrew

Abstract excerpt

McCune-Albright syndrome (MAS) is defined by the triad of café-au-lait skin pigmentation, polyostotic fibrous dysplasia, and hyperfunctioning endocrinopathies, such as precocious puberty, hyperthyroidism, GH excess, and Cushing's syndrome. This disorder is caused by sporadic, postzygotic activating mutations in the GNAS1 gene, which codes for the G(s)alpha protein in the cAMP signaling cascade. Nodular and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Clear Cell
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromogranins

Share to Fibrous Dysplasia, Polyostotic

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Heterotrimeric GTP-Binding Proteins

Share to Protein Subunits

Share to Thyroidectomy

Source

Identifiers

PMID: 12970318
DOI: 10.1210/jc.2002-021642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.PMID 12970318Read ↗

Hyperthyroidism in McCune-Albright syndrome with a review of thyroid abnormalities sixty years after the first report.Semantic proximity Read ↗

[Hyperthyroidism related to McCune-Albright syndrome: report of two cases and review of the literature].Semantic proximity Read ↗

McCune-Albright syndrome and disorders due to activating mutations of GNAS1.Semantic proximity Read ↗

A case of McCune-Albright syndrome with associated multiple endocrinopathies.Semantic proximity Read ↗

The curious case of Gαs gain-of-function in neoplasia.Semantic proximity Read ↗

Genetic diagnosis of multiple affected tissues in a patient with McCune-Albright syndrome.Semantic proximity Read ↗

Hepatobiliary and Pancreatic neoplasms in patients with McCune-Albright syndrome.Semantic proximity Read ↗

Nonautoimmune Hyperthyroidism Caused by a Somatic Mosaic GNAS Mutation Involving Part of the Thyroid Gland.Semantic proximity Read ↗

Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.Semantic proximity Read ↗

Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy.Semantic proximity Read ↗

A case of McCune-Albright syndrome associated with Gs alpha mutation in the bone tissue.Semantic proximity Read ↗

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.