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Article

Molecular dynamics simulations of the unfolding of beta(2)-microglobulin and its variants.

Protein engineering - 1 Aug 2003

Ma Buyong, Nussinov Ruth

Abstract excerpt

In this study, we examined the unfolding processes of native beta(2)-microglobulin and two related variants, one with an N-terminal hexapeptide deletion DeltaN6 and another with Lys57-Asp58 cleavage, by high-temperature molecular dynamics simulations. Three simulation models were used, molecular dynamics (MD) simulations with explicit water solvation, MD simulations with the CHARMM EEF1 force field and Langevin...

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Identifiers

PMID: 12968074
DOI: 10.1093/protein/gzg079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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