Using multiple drug exposure levels to optimize power in pharmacogenetic trials.

Abstract excerpt

Large-scale pharmacogenetic trials testing tens to hundreds of thousands of single-nucleotide polymorphisms (SNPs) will become possible in the near future given rapidly decreasing costs of genotyping. Devising optimal designs for these trials will be a significant challenge. The author demonstrates how the level of drug exposure may strongly affect the power to detect true associations between genetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Genotype
• Share to Models, Genetic