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Article

Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks.

Journal of cell science - 15 Oct 2003

Ivanov Andrei, Cragg Mark S, Erenpreisa Jekaterina, Emzinsh Dzintars, Lukman Henny, Illidge Timothy M

Abstract excerpt

p53 mutant tumour cells respond to genotoxic insults by bypassing G1 arrest and halting in G2. Following release from G2 arrest they undergo mitotic catastrophe, whereby mitotic cycling is suppressed, delayed apoptosis begins and endopolyploid cells are produced. The ability of these endopolyploi...

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Identifiers

PMID: 12953071
DOI: 10.1242/jcs.00740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12953071-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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