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Article

Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations

1 Aug 2006

Abstract excerpt

Topoisomerase II (Topo II) inhibitors are cell cycle-specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). In spite of the clinical importance, the molecular mechanism for this chromosomal translocation has yet to be elucidated. In this study, we employed...

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PMID: 16357944
DOI: 10.1172/jci25716e1

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