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Article

Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli.

Journal of bacteriology - 1 Sept 2003

Meisel Ute, Höltje Joachim-Volker, Vollmer Waldemar

Abstract excerpt

Penicillin-binding protein 1B (PBP1B) of Escherichia coli is a bifunctional murein synthase containing both a transpeptidase domain and a transglycosylase domain. The protein is present in three forms (alpha, beta, and gamma) which differ in the length of their N-terminal cytoplasmic region. Expression plasmids allowing the production of native PBP1B or of PBP1B variants with an inactive transpeptidase or...

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Identifiers

PMID: 12949085
DOI: 10.1128/JB.185.18.5342-5348.2003
PMCID: PMC193747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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