Article
A murein hydrolase is the specific target of bulgecin in Escherichia coli.
The Journal of biological chemistry - 5 Oct 1992
Templin M F, Edwards D H, Höltje J V
Abstract excerpt
A deletion in the structural gene for the soluble lytic transglycosylase, the predominant murein hydrolase in the soluble fraction of Escherichia coli, has been constructed. The mutant grows normally but exhibits increased sensitivity toward mecillinam, a beta-lactam specific for penicillin-bindi...
Topics
- Amdinocillin
- Azlocillin
- Blotting, Western
- Escherichia coli
- Gene Deletion
- Genes, Bacterial
- Glycopeptides
- Glycosyltransferases
- Imidazolidines
- Kinetics
- Microbial Sensitivity Tests
- Phenotype