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Article

Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition.

The Journal of biological chemistry - 7 Nov 2003

Putney Luanna K, Barber Diane L

Abstract excerpt

It is well established that activation of the Na-H exchanger NHE1 and increases in intracellular pH (pHi) are early and universal responses to mitogens and have permissive effects in promoting cell proliferation. Despite this evidence, a specific role for NHE1 or pHi in cell cycle progression remains undetermined. We now show that NHE1 activity and pHi regulate the timing of G2/M entry and transition. Prior to...

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Identifiers

PMID: 12947095
DOI: 10.1074/jbc.M308099200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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