Induction of an invasive phenotype in benign tumor cells with a laminin A-chain synthetic peptide.

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Article

Induction of an invasive phenotype in benign tumor cells with a laminin A-chain synthetic peptide.

Invasion & metastasis - 1 Jan 1992

Royce L S, Martin G R, Kleinman H K

Abstract excerpt

K-1735 clones 10 and M2 are cell lines cloned from a UV-induced murine melanoma. While both lines are highly tumorigenic, only the M2 cells are highly invasive in vitro and metastatic in vivo. Here we have exposed the clone 10 cells to the synthetic peptide PA22-2, which contains the IKVAV sequence from the A chain of laminin and which, like laminin, induces collagenase IV production and enhances metastasis...

Topics

Amino Acid Sequence
Animals
Clone Cells
Collagen
Collagenases
Drug Combinations
Enzyme Induction
Laminin
Macromolecular Substances
Matrix Metalloproteinase 9
Melanoma, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Neoplasm Invasiveness

Neoplasm Metastasis

Peptide Fragments

Peptides

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1294529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1294529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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